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Version: 17.06d (Release date: 2017-06-26)
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Lonafarnib (Code C1829)

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Terms & Properties

Preferred Name: Lonafarnib

Definition: A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called enzyme inhibitors.

Display Name: Lonafarnib

Label: Lonafarnib

NCI Thesaurus Code: C1829 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1257385  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-[2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
Lonafarnib
LONAFARNIB
lonafarnib
Sarasar
SCH-66336
SCH66336
SCH 66336

External Source Codes: 
CAS Registry Number 193275-84-2 (see NLM ChemIDplus info)
FDA UNII Code IOW153004F
NSC Code 719467 (see NCI DTP info)
PDQ Closed Trial Search ID 43503
PDQ Open Trial Search ID 43503 (check for NCI PDQ open clinical trial info)
UMLS CUI C1257385

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H31Br2ClN4O2
code C1829
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lonafarnib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1829

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