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Version: 16.11d (Release date: 2016-11-28)
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Mitomycin (Code C1820)

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Terms & Properties

Preferred Name: Mitomycin

Definition: A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)

Display Name: Mitomycin

Label: Mitomycin

NCI Thesaurus Code: C1820 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0002475  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
[1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
Ametycine
MITO
MITO-C
Mito-C
Mito-Medac
Mitocin
Mitocin-C
Mitolem
Mitomycin
MITOMYCIN
Mitomycin-C
Mitomycin-X
Mitomycine C
MITOMYCIN C
Mitomycin C
Mitosol
Mitozytrex
Mutamycin
Mutamycine
NCI-C04706

External Source Codes: 
CAS Registry Number 50-07-7 (see NLM ChemIDplus info)
FDA UNII Code 50SG953SK6
ChEBI ID CHEBI:27504 (see ChEBI info)
NSC Code 26980 (see NCI DTP info)
PDQ Closed Trial Search ID 42674
PDQ Open Trial Search ID 42674 (check for NCI PDQ open clinical trial info)
UMLS CUI C0002475

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Gastric Carcinoma
Accepted_Therapeutic_Use_For Pancreatic Adenocarcinoma
Chemical_Formula C15H18N4O5
code C1820
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mitomycin_C
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1820

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