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Version: 16.10e (Release date: 2016-10-31)
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Hydrocortisone Sodium Succinate (Code C1819)

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Terms & Properties

Preferred Name: Hydrocortisone Sodium Succinate

Definition: The sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation.

Display Name: Hydrocortisone Sodium Succinate

Label: Hydrocortisone Sodium Succinate

NCI Thesaurus Code: C1819 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0770560  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(11beta)-21-(3-Carboxy-1-oxopropyl)-11,17-dihydroxypregn-4-ene-3,20-dione, Monosodium Salt
A-Hydrocort
Buccalsone
Corlan
Cortisol Sodium Succinate
Cortisol sodium succinate
Cortop
Efcortelan
Emergent-EZ
Flebocortid
Hidroc Clora
Hycorace
Hydro-Adreson
Hydro-adreson
Hydrocort
Hydrocortisone 21-Sodium Succinate
Hydrocortisone Na Succinate
Hydrocortisone Sodium Succinate
HYDROCORTISONE SODIUM SUCCINATE
Hydrocortisone sodium succinate
Kinogen
Nordicort
Nositrol
Sinsurrene
Sodium hydrocortisone succinate
Solu-Cortef
Solu-Glyc

External Source Codes: 
CAS Registry Number 125-04-2 (see NLM ChemIDplus info)
FDA UNII Code 50LQB69S1Z
NSC Code 9152 (see NCI DTP info)
PDQ Closed Trial Search ID 39861
PDQ Open Trial Search ID 39861 (check for NCI PDQ open clinical trial info)
UMLS CUI C0770560

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C25H33O8.Na
code C1819
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Hydrocortisone_Sodium_Succinate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1819

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