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Version: 17.06d (Release date: 2017-06-26)
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Yttrium Y 90-DOTA-Biotin (Code C1808)

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Terms & Properties

Preferred Name: Yttrium Y 90-DOTA-Biotin

Definition: A radioconjugate of biotin and yttrium Y 90 (Y-90) linked through the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) with radioimmunotherapy property. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. Y 90-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs a tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin.

NCI-GLOSS Definition: A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. Yttrium Y 90 DOTA-biotin will find tumor cells in the body that have been targeted by an antibody linked to streptavidin and kill them. It is being studied together with CC49-streptavidin in the treatment of cancer.

Label: Yttrium Y 90-DOTA-Biotin

NCI Thesaurus Code: C1808 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0677849  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
90Y-DOTA-Biotin
90Y-DOTA-biotin
Yttrium Y 90-DOTA-Biotin
yttrium Y 90 DOTA-biotin

External Source Codes: 
PDQ Closed Trial Search ID 365680
PDQ Open Trial Search ID 365680 (check for NCI PDQ open clinical trial info)
UMLS CUI C0677849

Other Properties:
     Name Value (qualifiers indented underneath)
code C1808
Legacy_Concept_Name _90Y-DOTA-Biotin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1808

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