|Yttrium Y 90-DOTA-Biotin (Code C1808)|
|Terms & Properties|
Preferred Name: Yttrium Y 90-DOTA-Biotin
Definition: A radioconjugate of biotin and yttrium Y 90 (Y-90) linked through the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) with radioimmunotherapy property. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. Y 90-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs a tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin.
NCI-GLOSS Definition: A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. Yttrium Y 90 DOTA-biotin will find tumor cells in the body that have been targeted by an antibody linked to streptavidin and kill them. It is being studied together with CC49-streptavidin in the treatment of cancer.
Label: Yttrium Y 90-DOTA-Biotin
NCI Metathesaurus Link: C0677849 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
|Yttrium Y 90-DOTA-Biotin|
|yttrium Y 90 DOTA-biotin|
External Source Codes:
|PDQ Closed Trial Search ID||365680|
|PDQ Open Trial Search ID||365680 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|