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Version: 16.11d (Release date: 2016-11-28)
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Gemtuzumab Ozogamicin (Code C1806)

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Terms & Properties

Preferred Name: Gemtuzumab Ozogamicin

Definition: A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin. In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. (NCI04)

NCI-GLOSS Definition: A monoclonal antibody combined with a toxic substance that is used to treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Mylotarg is a type of antibody-drug conjugate.

Display Name: Gemtuzumab Ozogamicin

Label: Gemtuzumab Ozogamicin

NCI Thesaurus Code: C1806 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1533699  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Calicheamicin-Conjugated Humanized Anti-CD33 Monoclonal Antibody
CDP-771
CMA-676
gemtuzumab
Gemtuzumab Ozogamicin
GEMTUZUMAB OZOGAMICIN
gemtuzumab ozogamicin
hP67.6-Calicheamicin
Mylotarg
WAY-CMA-676

External Source Codes: 
CAS Registry Number 220578-59-6 (see NLM ChemIDplus info)
FDA UNII Code 8GZG754X6M
NSC Code 720568 (see NCI DTP info)
PDQ Closed Trial Search ID 42868
PDQ Open Trial Search ID 42868 (check for NCI PDQ open clinical trial info)
UMLS CUI C1533699

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute Myeloid Leukemia.
Chemical_Formula C73H96IN6O25S3
code C1806
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Gemtuzumab_Ozogamicin
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1806

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