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Version: 17.06d (Release date: 2017-06-26)
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Raltitrexed (Code C1804)

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Terms & Properties

Preferred Name: Raltitrexed

Definition: A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. (NCI04)

NCI-GLOSS Definition: An anticancer drug that stops tumor cells from growing by blocking the ability of cells to make DNA. It belongs to the family of drugs called thymidylate synthase inhibitors.

Display Name: Raltitrexed

Label: Raltitrexed

NCI Thesaurus Code: C1804 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0677667  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ICI D1694
N-(5-[N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic Acid
N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid

External Source Codes: 
CAS Registry Number 112887-68-0 (see NLM ChemIDplus info)
NSC Code 639186 (see NCI DTP info)
PDQ Closed Trial Search ID 42625
PDQ Open Trial Search ID 42625 (check for NCI PDQ open clinical trial info)
UMLS CUI C0677667

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H22N4O6S
code C1804
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Raltitrexed
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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