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Version: 16.10e (Release date: 2016-10-31)
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Etaracizumab (Code C1800)

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Terms & Properties

Preferred Name: Etaracizumab

Definition: A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha v beta 3 integrin. Etaracizumab blocks the binding of ligands, such as vitronectin, to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis. Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer and other conditions. Abegrin binds to a protein on the surface of blood vessels and may prevent the growth of new blood vessels that tumors need to grow. It may also prevent the spread of cancer. It is a type of antiangiogenesis agent, a type of metastasis inhibitor, and a type of monoclonal antibody.

Display Name: Etaracizumab

Label: Etaracizumab

NCI Thesaurus Code: C1800 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2350723  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Abegrin
Etaracizumab
ETARACIZUMAB
etaracizumab
Humanized Monoclonal Antibody LM609
humanized monoclonal antibody MEDI-522
MEDI-522
Monoclonal Antibody Anti-alpha V Beta 3 Integrin MEDI-522
Monoclonal Antibody Anti-Avb3 Integrin Medi-522
Vitaxin

External Source Codes: 
CAS Registry Number 892553-42-3 (see NLM ChemIDplus info)
FDA UNII Code 41W9MFI160
NSC Code 719850 (see NCI DTP info)
PDQ Closed Trial Search ID 38491
PDQ Open Trial Search ID 38491 (check for NCI PDQ open clinical trial info)
UMLS CUI C2350723

Other Properties:
Name Value (qualifiers indented underneath)
code C1800
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Vitaxin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1800

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