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Version: 16.11d (Release date: 2016-11-28)
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Shark Cartilage Extract AE-941 (Code C1798)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Shark Cartilage Extract AE-941

Definition: A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.

NCI-GLOSS Definition: A substance made from shark cartilage that is being studied for its ability to prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.

Display Name: Shark Cartilage Extract AE-941

Label: Shark Cartilage Extract AE-941

NCI Thesaurus Code: C1798 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1963096  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[AElig]-941
AE-941
Neovastat
Shark Cartilage Extract AE-941

External Source Codes: 
CAS Registry Number 305838-77-1 (see NLM ChemIDplus info)
NSC Code 706456 (see NCI DTP info)
PDQ Closed Trial Search ID 42021
PDQ Open Trial Search ID 42021 (check for NCI PDQ open clinical trial info)
UMLS CUI C1963096

Other Properties:
Name Value (qualifiers indented underneath)
code C1798
Contributing_Source CTRP
Legacy_Concept_Name Neovastat
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1798

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