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Version: 17.06d (Release date: 2017-06-26)
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Paclitaxel Poliglumex (Code C1795)

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Terms & Properties

Preferred Name: Paclitaxel Poliglumex

Definition: The agent paclitaxel linked to a biodegradable, water-soluble polyglutamate polymer with antineoplastic properties. The polyglutamate residue increases the water solubility of paclitaxel and allows delivery of higher doses than those achievable with paclitaxel alone. Paclitaxel promotes microtubule assembly and prevents microtubule depolymerization, thus interfering with normal mitosis.

NCI-GLOSS Definition: A form of the anticancer drug paclitaxel combined with a protein called poliglumex that may have fewer side effects and work better than paclitaxel. It is being studied in the treatment of breast cancer, ovarian cancer, lung cancer, and other types of cancer. It belongs to the family of drugs called mitotic inhibitors.

Display Name: Paclitaxel Poliglumex

Label: Paclitaxel Poliglumex

NCI Thesaurus Code: C1795 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1702776  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CT-2103
Paclitaxel-Polyglutamate Polymer
Paclitaxel Poliglumex
PACLITAXEL POLIGLUMEX
paclitaxel poliglumex
paclitaxel polyglutamate
Paclitaxel Polyglutamate
PG-TXL
Poly-L-Glutamic acid-Paclitaxel Conjugate
Polyglutamic Acid Paclitaxel
Xyotax

External Source Codes: 
CAS Registry Number 263351-82-2 (see NLM ChemIDplus info)
FDA UNII Code TQ64FZ98ZN
NSC Code 724773 (see NCI DTP info)
PDQ Closed Trial Search ID 38325
PDQ Open Trial Search ID 38325 (check for NCI PDQ open clinical trial info)
UMLS CUI C1702776

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H16N2O7(C52H56N2O16)n(C5H7NO3)n
code C1795
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Paclitaxel_Polyglutamate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1795

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