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Version: 17.06d (Release date: 2017-06-26)
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Capecitabine (Code C1794)

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Terms & Properties

Preferred Name: Capecitabine

Definition: A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. (NCI04)

NCI-GLOSS Definition: A drug used to treat stage III colon cancer in patients who had surgery to remove the cancer. It is also used to treat metastatic breast cancer that has not improved after treatment with certain other anticancer drugs. Xeloda is being studied in the treatment of other types of cancer. It is taken up by cancer cells and breaks down into 5-fluorouracil, a substance that kills tumor cells. Xeloda is a type of antimetabolite.

Display Name: Capecitabine

Label: Capecitabine

NCI Thesaurus Code: C1794 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0671970  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine
Capecitabine
CAPECITABINE
capecitabine
Ro 09-1978/000
Xeloda

External Source Codes: 
CAS Registry Number 154361-50-9 (see NLM ChemIDplus info)
FDA UNII Code 6804DJ8Z9U
ChEBI ID CHEBI:31348 (see ChEBI info)
NSC Code 712807 (see NCI DTP info)
PDQ Closed Trial Search ID 42852
PDQ Open Trial Search ID 42852 (check for NCI PDQ open clinical trial info)
UMLS CUI C0671970

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer; Colorectal cancer, Stage III colon cancer
Chemical_Formula C15H22FN3O6
code C1794
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Capecitabine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1794

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