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Version: 17.12d (Release date: 2017-12-26)
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Cisplatin-E Therapeutic Implant (Code C17879)

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Terms & Properties

Preferred Name: Cisplatin-E Therapeutic Implant

Definition: An injectable gel comprised of a collagen matrix containing the inorganic platinum (Pt) agent cisplatin and the sympathomimetic agent epinephrine with potential antineoplastic activity. After intratumoral injection, cisplatin forms highly reactive, positively charged, platinum complexes, which covalently bind to nucleophilic groups in DNA, preferably at the N7 position of guanine bases. This induces both intra- and inter-strand DNA cross-links. In addition, cisplatin forms DNA-Pt-protein cross-links. Cross-link formation results in both the induction of apoptosis and cell growth inhibition. Epinephrine, a potent vasoconstrictor, is added to the gel to both enhance the penetration of cisplatin into tumor tissue and reduce its dispersion into the surrounding tissues. Intratumoral injection of cisplatin-E therapeutic implant may increase local chemotherapeutic efficacy, as compared to the systemic administration of cisplatin, while reducing its systemic toxicity.

Label: Cisplatin-E Therapeutic Implant

NCI Thesaurus Code: C17879 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0677669  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CDDP-e therapeutic implant
CDDP/epi gel
Cisplatin-E Therapeutic Implant
Cisplatin/Epinephrine Gel
Intradose MPI-5010
MP 5010 Therapeutic Implant
MP 5010 TI
MPI 5010

External Source Codes: 
PDQ Closed Trial Search ID 42697
PDQ Open Trial Search ID 42697 (check for NCI PDQ open clinical trial info)
UMLS CUI C0677669

Other Properties:
     Name Value (qualifiers indented underneath)
code C17879
Legacy_Concept_Name Cisplatin-E_Therapeutic_Implant
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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