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Version: 16.10e (Release date: 2016-10-31)
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Fluorouracil-E Therapeutic Implant (Code C17877)

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Terms & Properties

Preferred Name: Fluorouracil-E Therapeutic Implant

Definition: An injectable collagen matrix gel containing the antimetabolite fluorouracil and the sympathicomimetic agent epinephrine with potential antineoplastic activity. After intratumoral injection, fluorouracil is converted into the active metabolite 5-fluoroxyuridine monophosphate that competes with uracil during RNA synthesis while another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate, inhibits thymidylate synthase and, so, DNA synthesis. Epinephrine, a potent vasoconstrictor, is added to the gel to enhance penetration of fluorouracil into tumor tissue and reduce dispersion to surrounding tissues, thus enhancing the local concentration of fluorouracil. Compared to systemic administration, the intratumoral injection of fluorouracil combined with epinephrine may increase fluorouracil's chemotherapeutic efficacy while minimizing systemic toxicity.

Label: Fluorouracil-E Therapeutic Implant

NCI Thesaurus Code: C17877 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0281426  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Fluorouracil/epi
5-FU-e TI
5-FU/epi gel
Fluorouracil-epinephrine therapeutic implant
Fluorouracil-E Therapeutic Implant
Fluorouracil/epi

External Source Codes: 
PDQ Closed Trial Search ID 41859
PDQ Open Trial Search ID 41859 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281426

Other Properties:
Name Value (qualifiers indented underneath)
code C17877
Legacy_Concept_Name Fluorouracil-E_Therapeutic_Implant
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C17877

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