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Version: 17.06d (Release date: 2017-06-26)
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Methotrexate-E Therapeutic Implant (Code C17876)

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Terms & Properties

Preferred Name: Methotrexate-E Therapeutic Implant

Definition: An injectable collagen matrix gel containing the antimetabolite methotrexate and the sympathicomimetic agent epinephrine with potential antineoplastic activity. After intratumoral injection, methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Epinephrine, a potent vasoconstrictor, is added to the gel to enhance penetration of methotrexate into the tumor tissue and reduce dispersion to the surrounding tissues thereby enhancing the local concentration of methotrexate and increasing its anti-tumor activity. Intratumoral injection of methotrexate combined with epinephrine may potentially increase chemotherapeutic efficacy compared to systemic administration and reduce systemic toxicity and side effects.

Label: Methotrexate-E Therapeutic Implant

NCI Thesaurus Code: C17876 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0281425  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Methotrexate-epinephrine therapeutic implant
Methotrexate-E Therapeutic Implant
MTX/epi gel

External Source Codes: 
PDQ Closed Trial Search ID 41858
PDQ Open Trial Search ID 41858 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281425

Other Properties:
     Name Value (qualifiers indented underneath)
code C17876
Legacy_Concept_Name Methotrexate-E_Therapeutic_Implant
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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