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Version: 17.06d (Release date: 2017-06-26)
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Plerixafor (Code C1777)

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Terms & Properties

Preferred Name: Plerixafor

Definition: A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation.

NCI-GLOSS Definition: A drug used before autologous stem cell transplantation in patients with non-Hodgkin lymphoma or multiple myeloma. Plerixafor is given together with granulocyte-colony stimulating factor (G-CSF) to help move stem cells from the bone marrow to the blood. The stem cells can then be collected, stored, and given back to the patient. Plerixafor is a type of chemokine receptor antagonist.

Display Name: Plerixafor

Label: Plerixafor

NCI Thesaurus Code: C1777 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0257001  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,1'-[1,4-Phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
AMD 3100
JM-3100
Mozobil
Plerixafor
plerixafor
PLERIXAFOR
SDZ SID 791

External Source Codes: 
CAS Registry Number 110078-46-1 (see NLM ChemIDplus info)
FDA UNII Code S915P5499N
PDQ Closed Trial Search ID 410786
PDQ Open Trial Search ID 410786 (check for NCI PDQ open clinical trial info)
UMLS CUI C0257001

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hematopoietic Stem Cell Mobilization
Chemical_Formula C28H54N8
code C1777
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name AMD3100
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1777

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