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Version: 17.06d (Release date: 2017-06-26)
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Eniluracil (Code C1773)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Eniluracil

Definition: An orally-active fluoropyrimidine analogue. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil (5-FU) in the liver. Co-administration of ethynyluracil permits the oral administration of 5-FU.

NCI-GLOSS Definition: An anticancer drug that increases the effectiveness of fluorouracil.

Display Name: Eniluracil

Label: Eniluracil

NCI Thesaurus Code: C1773 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0098361  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Ethynyl-2,4(1H,3H)-pyrimidinedione
5-Ethynyluracil
5-ethynyluracil
5-Fluorouracil Enhancer
776C85
Eniluracil
eniluracil
ENILURACIL
ethynyluracil
GW776

External Source Codes: 
CAS Registry Number 59989-18-3 (see NLM ChemIDplus info)
FDA UNII Code 2E2W0W5XIU
NSC Code 687296 (see NCI DTP info)
PDQ Closed Trial Search ID 42692
PDQ Open Trial Search ID 42692 (check for NCI PDQ open clinical trial info)
UMLS CUI C0098361

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C6H4N2O2
code C1773
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ethynyluracil
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1773

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