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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interleukin-1-alpha (Code C1754)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant Interleukin-1-alpha

Definition: A recombinant agent which is chemically identical to or similar to the endogenous protein cytokine interleukin-1 (IL-1). The IL-1 precursor is produced by monocytes, activated macrophages, and other cell types; mature IL-1 is generated by proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE). This agent enhances T cell proliferation and B cell growth and differentiation and induces the expression of proinflammatory cytokines. (NCI04)

Label: Recombinant Interleukin-1-alpha

NCI Thesaurus Code: C1754 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1523980  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IL-1-alfa
interleukin-1-alpha
Recombinant Interleukin-1-alpha

External Source Codes: 
PDQ Closed Trial Search ID 523327
PDQ Open Trial Search ID 523327 (check for NCI PDQ open clinical trial info)
UMLS CUI C1523980

Other Properties:
     Name Value (qualifiers indented underneath)
code C1754
Legacy_Concept_Name Recombinant_Interleukin-1-alpha
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1754

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