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Version: 16.11d (Release date: 2016-11-28)
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Vincristine Sulfate (Code C1739)

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Terms & Properties

Preferred Name: Vincristine Sulfate

Definition: The sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.

NCI-GLOSS Definition: A drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Oncovin is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent.

Display Name: Vincristine Sulfate

Label: Vincristine Sulfate

NCI Thesaurus Code: C1739 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0591904  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Kyocristine
Leurocristine, sulfate
Leurocristine Sulfate
Leurocristine sulfate
Oncovin
Vincasar
Vincosid
Vincrex
Vincristine, sulfate
Vincristine Sulfate
VINCRISTINE SULFATE
vincristine sulfate

External Source Codes: 
CAS Registry Number 2068-78-2 (see NLM ChemIDplus info)
FDA UNII Code T5IRO3534A
NSC Code 67574 (see NCI DTP info)
PDQ Closed Trial Search ID 42251
PDQ Open Trial Search ID 42251 (check for NCI PDQ open clinical trial info)
UMLS CUI C0591904

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Neuroblastoma
Chemical_Formula C46H56N4O10.H2O4S
code C1739
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Vincristine_Sulfate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1739

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