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National Cancer Institute
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Version: 16.11d (Release date: 2016-11-28)
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Streptavidin (Code C17334)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Streptavidin

Definition: A bacterial protein that has high affinity for biotin. The non-covalent streptavidin-biotin complex is resistant to organic solvents, denaturants, detergents, proteolytic enzymes, and extremes in temperatures and pH. The stability of the complex is leveraged by many research and clinical procedures including protein purification, chemiluminescent, fluorescent and colorimetric immunostaining, atomic force microscopy, synthesis of carbon nanotubes and DNA-based nanoparticles, and targeted immunotherapy.

NCI-GLOSS Definition: A small bacterial protein that binds with high affinity to the vitamin biotin. This streptavidin-biotin combination can be used to link molecules such as radioisotopes and monoclonal antibodies together. These bound products have the property of being attracted to, and attaching to, cancer cells, rather than normal cells. The radiolabeled products are more easily removed from the body, thus decreasing their toxicity.

Label: Streptavidin

NCI Thesaurus Code: C17334 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0075278  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Streptavidin
streptavidin

External Source Codes: 
PDQ Closed Trial Search ID 42952
PDQ Open Trial Search ID 42952 (check for NCI PDQ open clinical trial info)
UMLS CUI C0075278

Other Properties:
Name Value (qualifiers indented underneath)
code C17334
Legacy_Concept_Name Streptavidin
Semantic_Type Biologically Active Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C17334

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