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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Perifosine (Code C1727)

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Terms & Properties

Preferred Name: Perifosine

Definition: An orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called alkylphospholipids.

Display Name: Perifosine

Label: Perifosine

NCI Thesaurus Code: C1727 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0754570  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium, Inner Salt

External Source Codes: 
CAS Registry Number 157716-52-4 (see NLM ChemIDplus info)
FDA UNII Code 2GWV496552
NSC Code 639966 (see NCI DTP info)
PDQ Closed Trial Search ID 43408
PDQ Open Trial Search ID 43408 (check for NCI PDQ open clinical trial info)
UMLS CUI C0754570

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H52NO4P
code C1727
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Perifosine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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