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Version: 16.10e (Release date: 2016-10-31)
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Irofulven (Code C1717)

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Terms & Properties

Preferred Name: Irofulven

Definition: A semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and protein macromolecules, forms adducts, and arrests cells in the S-phase of the cell cycle. This agent requires NADPH-dependent metabolism by alkenal/one oxidoreductase for activity. Irofulven is more active in vitro against tumor cells of epithelial origin and is more resistant to deactivation by p53 loss and MDR1 than other alkylating agents. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. Irofulven attaches to the cell's DNA and may block cancer cell growth. It is a type of alkylating agent.

Display Name: Irofulven

Label: Irofulven

NCI Thesaurus Code: C1717 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0532362  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(R)-6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro(cyclopropane-1,5'(5H)-inden)-7'(6'H)-one
6-Hydroxymethylacylfulvene
6-hydroxymethylacylfulvene
HMAF
Hydroxymethylacylfulvene
Irofulven
IROFULVEN
irofulven
MGI-114
MGI 114

External Source Codes: 
CAS Registry Number 158440-71-2 (see NLM ChemIDplus info)
FDA UNII Code 6B799IH05A
NSC Code 683863 (see NCI DTP info)
PDQ Closed Trial Search ID 43097
PDQ Open Trial Search ID 43097 (check for NCI PDQ open clinical trial info)
UMLS CUI C0532362

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C15H18O3
code C1717
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Irofulven
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1717

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