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Version: 17.08d (Release date: 2017-08-28)
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Recombinant Flt3 Ligand (Code C1714)

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Terms & Properties

Preferred Name: Recombinant Flt3 Ligand

Definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine Flt3. Flt3 ligand binds to the Flt3 tyrosine kinase receptor and, synergistically with other growth factors, stimulates the proliferation and mobilization of bone marrow precursor cells, including CD34+ cells, and dendritic cells. When proteolytically cleaved, the transmembrane isoform of Flt3 ligand generates the soluble form soluble Flt3 ligand, which is also biologically active.

NCI-GLOSS Definition: A drug that increases the number of immune cells and may stimulate the immune system to kill cancer cells.

Label: Recombinant Flt3 Ligand

NCI Thesaurus Code: C1714 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0249989  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FLT3 Ligand
FLT 3 Ligand
Recombinant Flt3 Ligand

External Source Codes: 
NSC Code 696599 (see NCI DTP info)
PDQ Closed Trial Search ID 42928
PDQ Open Trial Search ID 42928 (check for NCI PDQ open clinical trial info)
UMLS CUI C0249989

Other Properties:
     Name Value (qualifiers indented underneath)
code C1714
Legacy_Concept_Name Therapeutic_Flt3_Ligand
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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