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Version: 16.10e (Release date: 2016-10-31)
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Sabarubicin (Code C1706)

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Terms & Properties

Preferred Name: Sabarubicin

Definition: A disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin. Sabarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces apoptosis through a p53-independent mechanism. Sabarubicin is less cardiotoxic than doxorubicin.

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called antitumor antibiotics.

Label: Sabarubicin

NCI Thesaurus Code: C1706 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0664590  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(7S,9S)-7-{(4-O-(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)oxy}-6,9,11-trihydroxy-9-(hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione
BMS-195615
MEN-10755
SABARUBICIN
Sabarubicin

External Source Codes: 
CAS Registry Number 211100-13-9 (see NLM ChemIDplus info)
FDA UNII Code XS499WOZ93
PDQ Closed Trial Search ID 42684
PDQ Open Trial Search ID 42684 (check for NCI PDQ open clinical trial info)
UMLS CUI C0664590

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C32H37NO13
code C1706
Contributing_Source FDA
Legacy_Concept_Name MEN-10755
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1706

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