|Sabarubicin (Code C1706)|
|Terms & Properties|
Preferred Name: Sabarubicin
Definition: A disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin. Sabarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces apoptosis through a p53-independent mechanism. Sabarubicin is less cardiotoxic than doxorubicin.
NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
NCI Metathesaurus Link: C0664590 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||211100-13-9 (see NLM ChemIDplus info)|
|FDA UNII Code||XS499WOZ93|
|PDQ Closed Trial Search ID||42684|
|PDQ Open Trial Search ID||42684 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|