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Version: 17.08d (Release date: 2017-08-28)
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Tanomastat (Code C1705)

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Terms & Properties

Preferred Name: Tanomastat

Definition: A biphenyl matrix metalloproteinase (MMP) inhibitor (MMPI) with potential antineoplastic activity. Tanomastat inhibits MMP-2, MMP-3, and MMP-9, inhibiting extracellular matrix degradation and potentially inhibiting angiogenesis, tumor growth and invasion, and metastasis. MMPs consist of at least 18 zinc-containing endo-proteinases that are capable of degrading collagen and proteoglycan.

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.

Label: Tanomastat

NCI Thesaurus Code: C1705 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0393069  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-3-[(4'-Chloro-4-biphenylyl)carbonyl]-2-[(phenylthio)methyl]propionic acid
4-[4-(chlorophenyl)phenyl]-4-oxo-2S-(phenylthiomethyl) butanoic acid
BAY-12-9566
BAY 12-9566
Tanomastat
TANOMASTAT

External Source Codes: 
CAS Registry Number 179545-77-8 (see NLM ChemIDplus info)
FDA UNII Code AM1ZX94EXH
PDQ Closed Trial Search ID 42675
PDQ Open Trial Search ID 42675 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 16442153 (see PubMed Primary Reference info)
UMLS CUI C0393069

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H19ClO3S
code C1705
Contributing_Source FDA
Legacy_Concept_Name Tanomastat
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1705

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