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Version: 16.10e (Release date: 2016-10-31)
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Nelarabine (Code C1704)

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Terms & Properties

Preferred Name: Nelarabine

Definition: An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)

NCI-GLOSS Definition: A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites.

Display Name: Nelarabine

Label: Nelarabine

NCI Thesaurus Code: C1704 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0907349  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Amino, 6-Methoxypurine Arabinoside
2-Amino-6-methoxypurine arabinoside
2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine
506U78
Arranon
Compound 506U78
GW506U78
Nelarabine
NELARABINE
nelarabine

External Source Codes: 
CAS Registry Number 121032-29-9 (see NLM ChemIDplus info)
FDA UNII Code 60158CV180
ChEBI ID CHEBI:63612 (see ChEBI info)
NSC Code 686673 (see NCI DTP info)
PDQ Closed Trial Search ID 43260
PDQ Open Trial Search ID 43260 (check for NCI PDQ open clinical trial info)
UMLS CUI C0907349

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For T-cell Acute Lymphoblastic Leukemia; T-cell Lymphoblastic Lymphoma
Chemical_Formula C11H15N5O5
code C1704
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Nelarabine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1704

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