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Version: 16.11d (Release date: 2016-11-28)
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Tipifarnib (Code C1703)

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Terms & Properties

Preferred Name: Tipifarnib

Definition: A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors.

Display Name: Tipifarnib

Label: Tipifarnib

NCI Thesaurus Code: C1703 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1176289  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
R115777
Tipifarnib
TIPIFARNIB
tipifarnib
Zarnestra

External Source Codes: 
CAS Registry Number 192185-72-1 (see NLM ChemIDplus info)
FDA UNII Code MAT637500A
NSC Code 702818 (see NCI DTP info)
PDQ Closed Trial Search ID 42626
PDQ Open Trial Search ID 42626 (check for NCI PDQ open clinical trial info)
UMLS CUI C1176289

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C27H22Cl2N4O
code C1703
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tipifarnib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1703

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