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Version: 17.06d (Release date: 2017-06-26)
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Rituximab (Code C1702)

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Terms & Properties

Preferred Name: Rituximab

Definition: A recombinant chimeric murine/human antibody directed against the CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes. Following binding, rituximab triggers a host cytotoxic immune response against CD20-positive cells. (NCI04)

NCI-GLOSS Definition: A drug used to treat certain types of B-cell non-Hodgkin lymphoma. It is also used with other drugs to treat chronic lymphocytic leukemia and rheumatoid arthritis. It is being studied in the treatment of other types of cancer and other conditions. Rituximab binds to a protein called CD20, which is found on B-cells, and may kill cancer cells. It is a type of monoclonal antibody.

Display Name: Rituximab

Label: Rituximab

NCI Thesaurus Code: C1702 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0393022  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABP 798
BI 695500
C2B8 Monoclonal Antibody
Chimeric Anti-CD20 Antibody
CT-P10
IDEC-102
IDEC-C2B8
IDEC-C2B8 Monoclonal Antibody
MabThera
Monoclonal Antibody IDEC-C2B8
PF-05280586
Rituxan
Rituximab
rituximab
RITUXIMAB
Rituximab Biosimilar ABP 798
Rituximab Biosimilar BI 695500
Rituximab Biosimilar CT-P10
Rituximab Biosimilar IBI301
Rituximab Biosimilar PF-05280586
Rituximab Biosimilar RTXM83
Rituximab Biosimilar SAIT101
RTXM83

External Source Codes: 
CAS Registry Number 174722-31-7 (see NLM ChemIDplus info)
FDA UNII Code 4F4X42SYQ6
ChEBI ID CHEBI:64357 (see ChEBI info)
NSC Code 687451 (see NCI DTP info)
PDQ Closed Trial Search ID 42613
PDQ Open Trial Search ID 42613 (check for NCI PDQ open clinical trial info)
UMLS CUI C0393022

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Diffuse Large B-cell, CD20-positive, Non-Hodgkins Lymphoma
code C1702
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Rituximab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1702

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