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Version: 16.11d (Release date: 2016-11-28)
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Zoledronic Acid (Code C1699)

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Terms & Properties

Preferred Name: Zoledronic Acid

Definition: A synthetic imidazole bisphosphonate analog of pyrophosphate with anti-bone-resorption activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. Decreased bone turnover and stabilization of the bone matrix contribute to the analgesic effect of zoledronic acid with respect to painful osteoblastic lesions. The agent also reduces serum calcium concentrations associated with hypercalcemia.

NCI-GLOSS Definition: A drug used to treat patients with hypercalcemia (high blood levels of calcium) caused by cancer. It is also used together with other drugs to treat multiple myeloma and to prevent bone fractures and reduce bone pain in people who have cancer that has spread to the bone. It is a type of bisphosphonate.

Display Name: Zoledronic Acid

Label: Zoledronic Acid

NCI Thesaurus Code: C1699 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0257685  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid
CGP42446A
CGP 42446
NDC-Zoledronate
Reclast
Zoledronic Acid
ZOLEDRONIC ACID
zoledronic acid
ZOL 446
Zometa

External Source Codes: 
CAS Registry Number 165800-06-6 (see NLM ChemIDplus info)
FDA UNII Code 6XC1PAD3KF
NSC Code 721517 (see NCI DTP info)
PDQ Closed Trial Search ID 42507
PDQ Open Trial Search ID 42507 (check for NCI PDQ open clinical trial info)
UMLS CUI C0257685

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hypercalcemia of malignancy; Multiple myeloma and metastatic bone lesions from solid tumors; Paget's disease
Chemical_Formula C5H10N2O7P2.H2O
code C1699
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Zoledronate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1699

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