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Version: 17.06d (Release date: 2017-06-26)
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Alemtuzumab (Code C1681)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Alemtuzumab

Definition: A recombinant DNA-derived humanized monoclonal antibody directed against the cell surface glycoprotein, CD52. Alemtuzumab is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions derived from a rat monoclonal antibody. This agent selectively binds to CD52, thereby triggering a host immune response that results in lysis of CD52 + cells. CD52 is a glycoprotein expressed on the surface of essentially all normal and malignant B and T cells, a majority of monocytes, macrophages and natural killer (NK) cells, a subpopulation of granulocytes, and tissues of the male reproductive system. (NCI04)

NCI-GLOSS Definition: A type of monoclonal antibody used in the treatment of leukemia. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.

Display Name: Alemtuzumab

Label: Alemtuzumab

NCI Thesaurus Code: C1681 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0383429  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alemtuzumab
ALEMTUZUMAB
alemtuzumab
Anti-CD52 Monoclonal Antibody
Campath
Campath-1H
LDP-03
Lemtrada
MabCampath
Monoclonal Antibody Campath-1H

External Source Codes: 
CAS Registry Number 216503-57-0 (see NLM ChemIDplus info)
FDA UNII Code 3A189DH42V
NSC Code 715969 (see NCI DTP info)
PDQ Closed Trial Search ID 37783
PDQ Open Trial Search ID 37783 (check for NCI PDQ open clinical trial info)
UMLS CUI C0383429

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic Lymphocytic Leukemia (CLL)
code C1681
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Alemtuzumab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1681

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