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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interleukin-18 (Code C1680)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant Interleukin-18

Definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-18 (IL-18). Produced primarily by macrophages, IL-18 induces the production of interferon-gamma (IFN-gamma), and enhances the activity of natural killer (NK) and cytotoxic T lymphocytes (CTL). As a potential immunotherapeutic agent, IL-18 displays antitumor effects in vitro and in animal models. (NCI04)

Display Name: Recombinant Interleukin-18

Label: Recombinant Interleukin-18

NCI Thesaurus Code: C1680 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1527127  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IFN-Gamma-Inducing Factor
Interferon-Gamma-Inducing Factor
Recombinant Interleukin-18

External Source Codes: 
PDQ Closed Trial Search ID 386168
PDQ Open Trial Search ID 386168 (check for NCI PDQ open clinical trial info)
UMLS CUI C1527127

Other Properties:
     Name Value (qualifiers indented underneath)
code C1680
Contributing_Source CTRP
Legacy_Concept_Name Therapeutic_Interleukin-18
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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