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Version: 16.10e (Release date: 2016-10-31)
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Exatecan Mesylate (Code C1679)

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Terms & Properties

Preferred Name: Exatecan Mesylate

Definition: A semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. (NCI04)

NCI-GLOSS Definition: An anticancer drug that is a type of topoisomerase inhibitor.

Label: Exatecan Mesylate

NCI Thesaurus Code: C1679 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935945  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DX-8951f
EXATECAN MESYLATE
Exatecan Mesylate
exatecan mesylate
Exatecan Mesylate Hydrate

External Source Codes: 
CAS Registry Number 197720-53-9 (see NLM ChemIDplus info)
FDA UNII Code D2VJ1CC26Q
PDQ Closed Trial Search ID 43386
PDQ Open Trial Search ID 43386 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935945

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C24H22FN3O4.CH4O3S.2H2O
code C1679
Contributing_Source FDA
Legacy_Concept_Name Exatecan_Mesylate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1679

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