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Version: 17.06d (Release date: 2017-06-26)
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Indium In-111 Pentetreotide (Code C1672)

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Terms & Properties

Preferred Name: Indium In-111 Pentetreotide

Definition: An indium 111 radioconjugate of pentetreotide, the diethylenetriaminopentaacetic (DTPA) conjugate of the human hormone somatostatin peptide analogue (octreotide), used for radioimaging neuroendocrine tumor cells. The pentetreotide moiety of indium In 111 pentetreotide binds to somatostatin receptors (SSTRs), especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and internalization, this radioconjugate allows for specific imaging of neuroendocrine tumors that overexpress somatostatin using scintigraphic imaging techniques. In addition, high dose indium In 111 pentetreotide may specifically deliver a cytotoxic dose of gamma radiation to SSTR-positive cells thereby killing SSTR-expressing tumor cells.

NCI-GLOSS Definition: An anticancer drug belonging to a family of drugs called radiopharmaceuticals.

Display Name: Indium In-111 Pentetreotide

Label: Indium In-111 Pentetreotide

NCI Thesaurus Code: C1672 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0379955  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Indium-111-DTPA-D-Phe-1-octreotide
Indium-In-111-Pentetreotide
Indium-In 111 Pentetreotide
Indium In-111 Pentetreotide
INDIUM IN-111 PENTETREOTIDE
Indium In 111-Pentetreotide
Indium In 111 Pentetreotide
indium In 111 pentetreotide
OctreoScan

External Source Codes: 
CAS Registry Number 139096-04-1 (see NLM ChemIDplus info)
FDA UNII Code M312JJ6Z32
PDQ Closed Trial Search ID 43127
PDQ Open Trial Search ID 43127 (check for NCI PDQ open clinical trial info)
UMLS CUI C0379955

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C63H83N13O19S2."H".In
code C1672
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name In_111_Pentetreotide
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1672

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