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Version: 17.08d (Release date: 2017-08-28)
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Ibandronate Sodium (Code C1670)

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Terms & Properties

Preferred Name: Ibandronate Sodium

Definition: The sodium salt form of ibandronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain.

NCI-GLOSS Definition: A drug that is used to prevent and treat osteoporosis, and is being studied in the treatment of cancer that has spread to the bones. It belongs to the family of drugs called bisphosphonates.

Display Name: Ibandronate Sodium

Label: Ibandronate Sodium

NCI Thesaurus Code: C1670 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0772244  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bondronate
Boniva
ibandronate
Ibandronate Sodium
IBANDRONATE SODIUM

External Source Codes: 
CAS Registry Number 138926-19-9 (see NLM ChemIDplus info)
FDA UNII Code J12U072QL0
PDQ Closed Trial Search ID 365963
PDQ Open Trial Search ID 365963 (check for NCI PDQ open clinical trial info)
UMLS CUI C0772244

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Osteoporosis, treatment and prevention
Chemical_Formula C9H22NO7P2.Na.H2O
code C1670
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ibandronate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1670

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