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Version: 17.06d (Release date: 2017-06-26)
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Temoporfin (Code C1669)

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Terms & Properties

Preferred Name: Temoporfin

Definition: A synthetic light-activated chlorin with photodynamic activity. Upon systemic administration, temoporfin distributes throughout the body and is taken up by tumor cells. Upon stimulation of temoporfin by non-thermal laser light (at 652 nm), and in the presence of oxygen, this agent produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to tumor cells. This may kill tumor cells and may reduce the tumor size.

NCI-GLOSS Definition: An anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called photosensitizing agents.

Display Name: Temoporfin

Label: Temoporfin

NCI Thesaurus Code: C1669 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0379149  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5,10,15,20-Tetra-(m-hydroxyphenyl)chlorin
Foscan
m-Tetrahydroxyphenyl-chlorin
meta-Tetrahydroxyphenylchlorin
meta-Tetrahydroxyphenyl Chlorin
mTHPC
Temoporfin
TEMOPORFIN
temoporfin

External Source Codes: 
CAS Registry Number 122341-38-2 (see NLM ChemIDplus info)
FDA UNII Code FU21S769PF
ChEBI ID CHEBI:9437 (see ChEBI info)
PDQ Closed Trial Search ID 42851
PDQ Open Trial Search ID 42851 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 17516041 (see PubMed Primary Reference info)
UMLS CUI C0379149

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C44H32N4O4
code C1669
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Temoporfin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1669

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