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Version: 17.06d (Release date: 2017-06-26)
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Biricodar Dicitrate (Code C1653)

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Terms & Properties

Preferred Name: Biricodar Dicitrate

Definition: The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein (P-gp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which may result in increased intracellular accumulation and retention of cytotoxic agents.

NCI-GLOSS Definition: A drug being studied to make cancer cells less resistant to the effects of chemotherapy.

Label: Biricodar Dicitrate

NCI Thesaurus Code: C1653 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0338354  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Biricodar Dicitrate
Incel VX-710

External Source Codes: 
CAS Registry Number 174254-13-8 (see NLM ChemIDplus info)
NSC Code 724636 (see NCI DTP info)
PDQ Closed Trial Search ID 42455
PDQ Open Trial Search ID 42455 (check for NCI PDQ open clinical trial info)
UMLS CUI C0338354

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C34H41N3O7.2C6H8O7
code C1653
Contributing_Source FDA
Legacy_Concept_Name Biricodar_Dicitrate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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