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Version: 16.11d (Release date: 2016-11-28)
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Marimastat (Code C1652)

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Terms & Properties

Preferred Name: Marimastat

Definition: An orally-active synthetic hydroxamate with potential antineoplastic activity. Marimastat covalently binds to the zinc(II) ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent may also inhibit tumor necrosis factor-alpha converting enzyme (TACE), an enzyme involved in tumor necrosis factor alpha (TNF-alpha) production that may play a role in some malignancies as well as in the development of arthritis and sepsis. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Marimastat is a matrix metalloproteinase inhibitor.

Label: Marimastat

NCI Thesaurus Code: C1652 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0338344  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic Acid
(2S,3R)-3-{(S)-[2,2-Dimethyl-1-(methylcarbamoyl) propyl]carbamoyl}-2-hydroxy-5-methylhexanohydroxamic acid
BB-2516
BB 2516
MARIMASTAT
Marimastat
marimastat
Marimistat
TA-2516

External Source Codes: 
CAS Registry Number 154039-60-8 (see NLM ChemIDplus info)
FDA UNII Code D5EQV23TDS
ChEBI ID CHEBI:50662 (see ChEBI info)
NSC Code 689451 (see NCI DTP info)
NSC Code 719333 (see NCI DTP info)
PDQ Closed Trial Search ID 42443
PDQ Open Trial Search ID 42443 (check for NCI PDQ open clinical trial info)
UMLS CUI C0338344

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C15H29N3O5
code C1652
Contributing_Source FDA
Legacy_Concept_Name Marimastat
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1652

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