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Version: 16.10e (Release date: 2016-10-31)
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Trastuzumab (Code C1647)

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Terms & Properties

Preferred Name: Trastuzumab

Definition: A recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). After binding to HER2 on the tumor cell surface, trastuzumab induces an antibody-dependent cell-mediated cytotoxicity against tumor cells that overexpress HER2. HER2 is overexpressed by many adenocarcinomas, particularly breast adenocarcinomas. (NCI04)

NCI-GLOSS Definition: A monoclonal antibody that binds to HER2 (human epidermal growth factor receptor 2), and can kill HER2-positive cancer cells. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Trastuzumab is used to treat breast cancer that is HER2-positive and has spread after treatment with other drugs. It is also used with other anticancer drugs to treat HER2-positive breast cancer after surgery. Trastuzumab is also being studied in the treatment of other types of cancer.

Display Name: Trastuzumab

Label: Trastuzumab

NCI Thesaurus Code: C1647 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0728747  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABP 980
Anti-c-ERB-2
Anti-c-erbB2 Monoclonal Antibody
Anti-ERB-2
Anti-erbB-2
Anti-erbB2 Monoclonal Antibody
Anti-HER2/c-erbB2 Monoclonal Antibody
Anti-p185-HER2
c-erb-2 Monoclonal Antibody
HER2 Monoclonal Antibody
Herceptin
Herceptin Biosimilar PF-05280014
Herceptin Trastuzumab Biosimilar PF-05280014
Immunoglobulin G 1 (Human-Mouse Monoclonal RhuMab HER2gamma1-Chain Antihuman p185(Sup c-erbB2) Receptor), Disulfide with Human-Mouse Monoclonal RhuMab HER2 Light Chain, Dimer
MoAb HER2
Monoclonal Antibody c-erb-2
Monoclonal Antibody HER2
PF-05280014
rhuMAb HER2
RO0452317
Trastuzumab
TRASTUZUMAB
trastuzumab
Trastuzumab Biosimilar ABP 980
Trastuzumab Biosimilar PF-05280014

External Source Codes: 
CAS Registry Number 180288-69-1 (see NLM ChemIDplus info)
FDA UNII Code P188ANX8CK
NSC Code 688097 (see NCI DTP info)
PDQ Closed Trial Search ID 42265
PDQ Open Trial Search ID 42265 (check for NCI PDQ open clinical trial info)
UMLS CUI C0728747

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer overexpressing HER2 protein; Pancreatic cancer overexpressing p185HER2
code C1647
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Trastuzumab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1647

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