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Version: 16.10e (Release date: 2016-10-31)
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Patupilone (Code C1623)

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Terms & Properties

Preferred Name: Patupilone

Definition: A compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of epothilone.

Display Name: Patupilone

Label: Patupilone

NCI Thesaurus Code: C1623 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0297960  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-Epothilone B
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
EPO-906A
EPO906
Epothilone B
epothilone B
Patupilone
PATUPILONE

External Source Codes: 
CAS Registry Number 152044-54-7 (see NLM ChemIDplus info)
FDA UNII Code UEC0H0URSE
PDQ Closed Trial Search ID 38702
PDQ Open Trial Search ID 38702 (check for NCI PDQ open clinical trial info)
UMLS CUI C0297960

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C27H41NO6S
code C1623
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Epothilone_B
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1623

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