|Patupilone (Code C1623)|
|Terms & Properties|
Preferred Name: Patupilone
Definition: A compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest.
NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of epothilone.
Display Name: Patupilone
NCI Metathesaurus Link: C0297960 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||152044-54-7 (see NLM ChemIDplus info)|
|FDA UNII Code||UEC0H0URSE|
|PDQ Closed Trial Search ID||38702|
|PDQ Open Trial Search ID||38702 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|