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Version: 17.06d (Release date: 2017-06-26)
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Becatecarin (Code C1620)

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Terms & Properties

Preferred Name: Becatecarin

Definition: A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called antitumor antibiotics and topoisomerase inhibitors.

Display Name: Becatecarin

Label: Becatecarin

NCI Thesaurus Code: C1620 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0936065  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-
Becatecarin
BECATECARIN
BMS-181176
BMY-27557-14
DEAE-Rebeccamycin
NSC 655649
Rebeccamycin analog
rebeccamycin analog
Rebeccamycin Analogue
Rebeccamycin Analogue, Tartrate Salt
XL119

External Source Codes: 
CAS Registry Number 119673-08-4 (see NLM ChemIDplus info)
FDA UNII Code A60X6MBU6G
NSC Code 655649 (see NCI DTP info)
PDQ Closed Trial Search ID 42257
PDQ Open Trial Search ID 42257 (check for NCI PDQ open clinical trial info)
UMLS CUI C0936065

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C33H34Cl2N4O7
code C1620
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Rebeccamycin_Analogue
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1620

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