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Version: 16.11d (Release date: 2016-11-28)
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LMB-7 Immunotoxin (Code C1619)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: LMB-7 Immunotoxin

Definition: A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. (NCI04)

NCI-GLOSS Definition: A toxic substance linked to an antibody that attaches to tumor cells and kills them.

Label: LMB-7 Immunotoxin

NCI Thesaurus Code: C1619 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0296314  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B3(Fv)-PE38
B3(Fv)-PE38 Immunotoxin
HB21(Fv)PE40
Immunotoxin LMB-7
LMB-7 (Single-Chain Immunotoxin)
LMB-7 Immunotoxin
LMB-7 immunotoxin

External Source Codes: 
NSC Code 658931 (see NCI DTP info)
NSC Code 659639 (see NCI DTP info)
PDQ Closed Trial Search ID 42683
PDQ Open Trial Search ID 42683 (check for NCI PDQ open clinical trial info)
UMLS CUI C0296314

Other Properties:
Name Value (qualifiers indented underneath)
code C1619
Legacy_Concept_Name LMB-7_Immunotoxin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1619

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