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Version: 17.06d (Release date: 2017-06-26)
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Nicotine Nasal Spray (Code C16162)

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Terms & Properties

Preferred Name: Nicotine Nasal Spray

Definition: A nasal spray composed of an aqueous solution containing the alkaloid nicotine with nicotine replacement activity. Upon administration of the spray into the nostrils, nicotine is taken up from the nasal mucosa into the bloodstream. Although nicotine binds to nicotinic cholinergic receptors at the autonomic ganglia, adrenal medulla and at neuromuscular junctions as well, the binding of nicotine to the receptors in the central nervous system (CNS) appears to be responsible for the addictive nature of nicotine. Binding to CNS nicotinic acetylcholine receptors causes the release of the neurotransmitter dopamine which appears to be responsible for the addiction of nicotine. Administration of nicotine may prevent nicotine craving and may help with the withdrawal symptoms associated with smoking cessation.

NCI-GLOSS Definition: A nose spray that contains a small dose of nicotine, which enters the blood by being absorbed through the lining of the nose. This helps stop nicotine cravings and relieves symptoms that occur when a person is trying to quit smoking. A prescription is needed for nicotine nasal spray.

Label: Nicotine Nasal Spray

NCI Thesaurus Code: C16162 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1249285  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Nicotine Nasal Spray
nicotine nasal spray
Nicotrol NS

External Source Codes: 
PDQ Closed Trial Search ID 663163
PDQ Open Trial Search ID 663163 (check for NCI PDQ open clinical trial info)
UMLS CUI C1249285

Other Properties:
     Name Value (qualifiers indented underneath)
code C16162
Legacy_Concept_Name Nicotine_Nasal_Spray
Semantic_Type Therapeutic or Preventive Procedure

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C16162

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