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National Cancer Institute
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Version: 16.11d (Release date: 2016-11-28)
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KRN5500 (Code C1614)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: KRN5500

Definition: A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus. KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions. This agent also induces cell differentiation and caspase-dependent apoptosis. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to a family of drugs called antitumor antibiotics. It is an anthracycline.

Display Name: KRN5500

Label: KRN5500

NCI Thesaurus Code: C1614 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0294829  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-[4-Deoxy-4-[(2E,4E)-tetradecadienoylglycyl]amino-L-glycero-beta-L-mannohepto-pyranosyl]amino-9H-purine
KRN5500

External Source Codes: 
NSC Code 650426 (see NCI DTP info)
PDQ Closed Trial Search ID 42581
PDQ Open Trial Search ID 42581 (check for NCI PDQ open clinical trial info)
UMLS CUI C0294829

Other Properties:
Name Value (qualifiers indented underneath)
code C1614
Contributing_Source CTRP
Legacy_Concept_Name KRN5500
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1614

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