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Version: 17.06d (Release date: 2017-06-26)
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Lurtotecan (Code C1610)

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Terms & Properties

Preferred Name: Lurtotecan

Definition: A semisynthetic analogue of camptothecin with antineoplastic activity. Lurtotecan selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. Independent from DNA replication inhibition, lurtotecan also inhibits RNA synthesis, multi-ubiquitination and degradation of topoisomerase I and chromatin reorganization.

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.

Label: Lurtotecan

NCI Thesaurus Code: C1610 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0293658  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin
GG 211
GI147211
Lurtotecan
lurtotecan
LURTOTECAN

External Source Codes: 
CAS Registry Number 149882-10-0 (see NLM ChemIDplus info)
FDA UNII Code 4J1L80T08I
PubMedID Primary Reference 15571957 (see PubMed Primary Reference info)
UMLS CUI C0293658

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C28H30N4O6
code C1610
Contributing_Source FDA
Legacy_Concept_Name Lurtotecan
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1610

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