|Lurtotecan (Code C1610)|
|Terms & Properties|
Preferred Name: Lurtotecan
Definition: A semisynthetic analogue of camptothecin with antineoplastic activity. Lurtotecan selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. Independent from DNA replication inhibition, lurtotecan also inhibits RNA synthesis, multi-ubiquitination and degradation of topoisomerase I and chromatin reorganization.
NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.
NCI Metathesaurus Link: C0293658 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||149882-10-0 (see NLM ChemIDplus info)|
|FDA UNII Code||4J1L80T08I|
|PubMedID Primary Reference||15571957 (see PubMed Primary Reference info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|