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Version: 17.06d (Release date: 2017-06-26)
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Ritonavir (Code C1609)

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Terms & Properties

Preferred Name: Ritonavir

Definition: A peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450.

NCI-GLOSS Definition: A drug used to treat infection with HIV (the virus that causes AIDS). It is also being studied in the treatment of some types of cancer. Ritonavir blocks the ability of HIV to make copies of itself and may block the growth of cancer cells. It is a type of anti-HIV agent and a type of protease inhibitor.

Display Name: Ritonavir

Label: Ritonavir

NCI Thesaurus Code: C1609 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0292818  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 155213-67-5 (see NLM ChemIDplus info)
FDA UNII Code O3J8G9O825
ChEBI ID CHEBI:45409 (see ChEBI info)
NSC Code 693184 (see NCI DTP info)
PDQ Closed Trial Search ID 42665
PDQ Open Trial Search ID 42665 (check for NCI PDQ open clinical trial info)
UMLS CUI C0292818

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C37H48N6O5S2
code C1609
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ritonavir
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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