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Version: 17.08d (Release date: 2017-08-28)
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Labradimil (Code C1606)

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Terms & Properties

Preferred Name: Labradimil

Definition: A synthetic analog of bradykinin. Lobradimil is a potent, specific bradykinin B-2 receptor agonist that stimulates B-2 receptors expressed on the surface of brain capillary endothelial cells, thereby reversibly increasing the permeability of the blood-brain barrier (BBB). Compared to bradykinin, this agent possesses enhanced receptor selectivity, greater plasma stability, and a longer half-life. (NCI04)

NCI-GLOSS Definition: A substance that is being studied for its ability to help other drugs reach the brain. It belongs to the family of drugs called bradykinin agonists.

Label: Labradimil

NCI Thesaurus Code: C1606 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0289630  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L-Prolinamide, L-Arginyl-L-prolyl-trans-4- hydroxy-L-prolyl-3-(2- thienyl)-L-alanylglycl -L-seryl-N-(2-((4-((aminoiminomethyl)amino)-1- -carboxybutyl)amino)-1-((4-methoxyphenyl)methyl)ethyl)-, (S-(R*,R*))

External Source Codes: 
CAS Registry Number 159768-75-9 (see NLM ChemIDplus info)
FDA UNII Code 2MK663C346
NSC Code 950021 (see NCI DTP info)
PDQ Closed Trial Search ID 42352
PDQ Open Trial Search ID 42352 (check for NCI PDQ open clinical trial info)
UMLS CUI C0289630

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C49H75N15O12S
code C1606
Contributing_Source FDA
Legacy_Concept_Name Lobradimil
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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