Terms & Properties

Preferred Name:  Anti-ILT4 Monoclonal Antibody MK-4830

Definition:  A human monoclonal antibody directed against the inhibitory immune checkpoint receptor immunoglobulin-like transcript 4 (ILT4; leukocyte immunoglobulin-like receptor subfamily B member 2; LILRB2; lymphocyte immunoglobulin-like receptor 2; LIR2; monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD85d), with potential immunomodulating and antineoplastic activities. Upon administration, anti-ILT4 monoclonal antibody MK-4830 targets and binds to ILT4. This prevents the binding of ILT4 ligands to their receptor and prevents ILT4-mediated signaling. This abrogates the immunosuppressive activities of ILT4 in the tumor microenvironment (TME), activates the expression of pro-inflammatory cytokines, including GM-CSF and tumor necrosis factor alpha (TNFalpha), and enhances a cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response. ILT4, plays a key role in tumor immune evasion. ILT4, a transmembrane protein and inhibitory member of the immunoglobulin-like transcript (ILT) family of proteins, is expressed primarily by myeloid cells, including monocytes, macrophages, dendritic cells (DCs) and granulocytes, and certain tumor cells.

Display Name:  Anti-ILT4 Monoclonal Antibody MK-4830

Label:  Anti-ILT4 Monoclonal Antibody MK-4830

NCI Thesaurus Code:  C160204 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  CL969335  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

Anti-ILT4 Monoclonal Antibody MK-4830

Anti-leukocyte Immunoglobulin-like Receptor 2 Monoclonal Antibody MK-4830

Anti-LIR2 Monoclonal Antibody MK-4830

MK 4830

MK-4830

MK4830

External Source Codes: 

NCI Drug Dictionary ID	797844 (see NCI Drug Dictionary info)
PDQ Closed Trial Search ID	797844
PDQ Open Trial Search ID	797844
NCI META CUI	CL969335

Other Properties:

Name	Value (qualifiers indented underneath)
code	C160204
Contributing_Source	CTRP
Contributing_Source	GDC
Maps_To	Anti-ILT4 Monoclonal Antibody MK-4830
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: therapeutic_agents
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C160204