skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Bicalutamide (Code C1599)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Bicalutamide

Definition: A synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called antiandrogens.

Display Name: Bicalutamide

Label: Bicalutamide

NCI Thesaurus Code: C1599 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0285590  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
4'-Cyano-alpha,alpha,alpha-trifuloro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide
4-Cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline
Bicalutamide
BICALUTAMIDE
bicalutamide
Casodex
Cosudex
ICI 176,334
ICI 176334
N-[4-Cyano-3-(trifluoromethyl)phenyl]3-3[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-propanamide

External Source Codes: 
CAS Registry Number 90357-06-5 (see NLM ChemIDplus info)
FDA UNII Code A0Z3NAU9DP
ChEBI ID CHEBI:3090 (see ChEBI info)
NSC Code 722665 (see NCI DTP info)
PDQ Closed Trial Search ID 41298
PDQ Open Trial Search ID 41298 (check for NCI PDQ open clinical trial info)
UMLS CUI C0285590

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Metastatic prostate cancer
Chemical_Formula C18H14F4N2O4S
code C1599
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Bicalutamide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1599

Mainbox Bottom