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Version: 16.10e (Release date: 2016-10-31)
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Gusperimus Trihydrochloride (Code C1598)

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Terms & Properties

Preferred Name: Gusperimus Trihydrochloride

Definition: A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. (NCI04)

Label: Gusperimus Trihydrochloride

NCI Thesaurus Code: C1598 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0284559  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+-)-15-Deoxyspergualin
1-Amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione
15-Deoxyspergualin
15-Deoxyspergualin Hydrochloride
7-[(Aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amnio]-1-hydroxy-2-oxoethyl]heptanamide
BMS-181173
BMY-42215-1
Deoxyspergualin
Deoxyspergualin Hydrochloride
DSG
GUSPERIMUS TRIHYDROCHLORIDE
Gusperimus Trihydrochloride
N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl]hydroxymethyl]-7-guanidinoheptanamide
NKT-01
Spanidin

External Source Codes: 
CAS Registry Number 84937-45-1 (see NLM ChemIDplus info)
FDA UNII Code QZS4144IO0
NSC Code 356894 (see NCI DTP info)
PDQ Closed Trial Search ID 40369
PDQ Open Trial Search ID 40369 (check for NCI PDQ open clinical trial info)
UMLS CUI C0284559

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C17H37N7O3.3HCl
code C1598
Contributing_Source FDA
Legacy_Concept_Name Gusperimus
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1598

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