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Version: 17.06d (Release date: 2017-06-26)
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Idarubicin Hydrochloride (Code C1587)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Idarubicin Hydrochloride

Definition: The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds

Display Name: Idarubicin Hydrochloride

Label: Idarubicin Hydrochloride

NCI Thesaurus Code: C1587 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0086450  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Idamycin
Idarubicin HCl
Idarubicin Hydrochloride
IDARUBICIN HYDROCHLORIDE
Idarubicin hydrochloride
IMI-30
SC-33428
Zavedos

External Source Codes: 
CAS Registry Number 57852-57-0 (see NLM ChemIDplus info)
FDA UNII Code 5VV3MDU5IE
NSC Code 256439 (see NCI DTP info)
UMLS CUI C0086450

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For In combination therapies for acute myelogenous leukemia and pediatric acute lymphocytic leukemia.
Chemical_Formula C26H27NO9.HCl
code C1587
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Idarubicin_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1587

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