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Version: 17.06d (Release date: 2017-06-26)
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Levofloxacin (Code C1586)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Levofloxacin

Definition: A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.

NCI-GLOSS Definition: A substance used to treat bacterial infections. It belongs to the family of drugs called quinolone antibiotics.

Display Name: Levofloxacin

Label: Levofloxacin

NCI Thesaurus Code: C1586 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0282386  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Levaquin
Levofloxacin
LEVOFLOXACIN
levofloxacin
Quixin

External Source Codes: 
CAS Registry Number 138199-71-0 (see NLM ChemIDplus info)
FDA UNII Code 6GNT3Y5LMF
PDQ Closed Trial Search ID 37941
PDQ Open Trial Search ID 37941 (check for NCI PDQ open clinical trial info)
UMLS CUI C0282386

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2C18H20FN3O4.H2O
code C1586
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Levofloxacin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1586

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