|Loperamide Hydrochloride (Code C1584)|
|Terms & Properties|
Preferred Name: Loperamide Hydrochloride
Definition: The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects.
NCI-GLOSS Definition: A drug used to treat diarrhea. Imodium slows the movement of the muscles in the small intestine to allow more water to be taken out of the feces (waste matter) and more nutrients to be absorbed.
Label: Loperamide Hydrochloride
NCI Metathesaurus Link: C0282221 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||34552-83-5 (see NLM ChemIDplus info)|
|FDA UNII Code||77TI35393C|
|PDQ Closed Trial Search ID||41911|
|PDQ Open Trial Search ID||41911 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|