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Version: 17.06d (Release date: 2017-06-26)
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Loperamide Hydrochloride (Code C1584)

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Terms & Properties

Preferred Name: Loperamide Hydrochloride

Definition: The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects.

NCI-GLOSS Definition: A drug used to treat diarrhea. Imodium slows the movement of the muscles in the small intestine to allow more water to be taken out of the feces (waste matter) and more nutrients to be absorbed.

Label: Loperamide Hydrochloride

NCI Thesaurus Code: C1584 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0282221  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Imodium A-D
Loperamide Hydrochloride
loperamide hydrochloride

External Source Codes: 
CAS Registry Number 34552-83-5 (see NLM ChemIDplus info)
FDA UNII Code 77TI35393C
PDQ Closed Trial Search ID 41911
PDQ Open Trial Search ID 41911 (check for NCI PDQ open clinical trial info)
UMLS CUI C0282221

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H33ClN2O2.HCl
code C1584
Contributing_Source FDA
Legacy_Concept_Name Loperamide_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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